针对抗菌性皮肤再生的NIR触发3D生物打印水凝
Hongyu Wen1,2, Qian Chen3, Peng Zhang1,2
1Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
Small (Weinheim an der Bergstrasse, Germany)
|January 29, 2026
概括
这项研究引入了使用上转化纳米粒子 (UCNPs) 进行近红外 (NIR) 触发的3D生物打印的新型水凝. 这些智能水凝提供了组合光动力学和光热疗法,以增强抗菌作用和皮肤再生.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 摄影化学的使用.
背景情况:
- 抗生素耐药性是一个日益增长的全球健康威胁.
- 需要先进的伤口愈合策略来对抗感染并促进组织再生.
- 水凝为药物输送和组织工程提供了有希望的平台.
研究的目的:
- 开发用于体内3D生物打印的NIR触发水凝.
- 为了研究这些水凝的联合光动力学和光热治疗效果.
- 评估这些水凝在促进皮肤再生和克服抗生素耐药性的潜力.
主要方法:
- 将上转化纳米颗粒 (UCNPs) 纳入聚烯酸-N-维尼尔-2-罗利 (AA-NVP) 和碳素甲基纤维素 (CMC) 水凝中.
- 使用NIR光用于结凝结和凝制造.
- 在生物体中3D生物打印水凝.
- 评估反应性氧物种 (ROS) 生产,光热效应 (PTE) 和抗菌功效.
- 在体内评估皮肤再生.
主要成果:
- 通过UCNP成功制造NIR触发的水凝.
- 证明了开发的水凝作为生物墨水的体内3D生物打印能力.
- 水凝通过联合光动力学疗法 (PDT) 和光热效应 (PTE) 显示出强大的杀菌作用.
- 观察到皮肤从内层到外层再生的显著促进.
结论:
- 开发的UCNPs内置的水凝为NIR触发的体内3D生物打印提供了一个新的平台.
- 通过PDT和PTE的协同抗菌疗法有效地规避了抗生素耐药性.
- 这些先进的水凝具有促进皮肤再生和治疗感染的巨大潜力.
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