在痛苦的关关疾病中研究功能性脑网络的变化:休息状态fMRI研究
Yujiao Jiang1,2, Xin Li3, Mengqi Liu1
1Department of Radiology, Hainan Hospital of PLA General Hospital, 572013 Sanya, Hainan, China.
Journal of oral & facial pain and headache
|January 29, 2026
概括
与疼痛相关的关节障碍 (TMDp) 显示大脑网络拓的改变. 在TMDp患者中,本地大脑网络的效率与抑郁和焦虑相关,为疼痛机制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 精神病学是一个精神病学.
背景情况:
- 部疾病 (TMD),特别是与疼痛相关的TMD (TMDp),与社会和心理因素有关.
- TMDp疼痛的潜在神经机制尚不清楚.
- 这项研究调查了TMDp患者的大脑网络的改变.
研究的目的:
- 通过静止状态功能磁共振成像 (rs-fMRI) 检查TMDp患者大脑网络的变化的拓性质.
- 探索这些拓性质与TMDp中的情感/临床变量之间的关系.
主要方法:
- 招募了41名TMDp患者和33名健康对照 (NC).
- 使用3.0TMR扫描仪获取的rs-fMRI数据.
- 计算和比较不同组之间的大脑功能网络拓性质,将发现与临床变量相关联.
主要成果:
- 与NCs相比,TMDp患者的聚类系数 (Cp) 和局部效率 (Eloc) 显著下降 (p <0.05).
- 在0.06的稀疏度值的Eloc值与TMDp患者的抑郁 (r = 0.319,p = 0.042) 和焦虑 (r = 0.348,p = 0.026) 变量正相关.
结论:
- 异常的大脑网络的拓变化在TMDp中很明显.
- 这些发现有助于理解TMDp疼痛的神经机制.
- 基于 rs-fMRI 的拓性质可以作为监测 TMDp 中大脑网络功能障碍的工具.
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