中性粒细胞水平与折断风险之间的性别特定关联:一项回顾性队列研究
Shuai Yuan1,2, Xiao-Jie Zhou1,2, Hao-Tian Jiao1,2
1Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China.
Frontiers in endocrinology
|January 29, 2026
概括
在4.4-8.5×10^9/L之间的中性粒细胞 (NEU) 水平显著降低了男性骨质疏松性骨折患者的折断风险. 这一发现凸显了NEU作为男性复发性骨折风险的潜在生物标志物.
科学领域:
- 整形外科 整形外科 整形外科
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 骨质疏松性骨折 (OPF) 是一个主要的全球健康问题,特别是在50岁以上的人群中.
- OPF的发病率和折射率很高,造成了很大的负担.
- 中性粒细胞 (NEU) 水平与复发性骨折风险之间的联系尚不清楚.
研究的目的:
- 研究入院时中性粒细胞水平与OPF患者复发骨折风险之间的关联.
- 探索潜在的非线性关系,并确定特定的中性粒细胞数值值.
- 为了确定中性粒细胞水平是否可以作为折断风险的预测生物标志物.
主要方法:
- 对2,474名接受手术的OPF患者 (2018-2023) 的回顾性队列研究.
- 在入院时测量了中性粒细胞计数;针对复发性骨折的患者进行了随访.
- 考克斯比例危险回归和平滑曲线适配用于分析5年折射风险.
主要成果:
- 在男性患者中观察到NEU水平和折射风险之间存在显著的西格形 (非线性) 关系.
- 4.4 - 8.5 ×10^9/L的NEU水平与大幅降低的折射风险相关 (HR=0.57,P=0.008).
- 在女性患者中,NEU水平和折射率之间没有发现显著的关联.
结论:
- 中性粒细胞水平与折断风险具有显著的西格状相关性,特别是在男性OPF患者中.
- 一个特定的NEU范围 (4.4 - 8.5 ×10 ^ 9 / L) 似乎可以保护男性的折射.
- 需要进一步的研究,以了解NEU作为男性折射风险生物标志物的潜在机制和临床实用性.
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