预后营养指数和全身免疫炎症指数的动态变化预测了卵巢癌的脱皮手术后的生存率
Karolin Ohanoglu Cetinel1, Gazi Guner2, Can Berk Karabudak1
1Basaksehir Cam and Sakura City Hospital Department of Obstetrics and Gynecology, Istanbul, Türkiye.
Frontiers in oncology
|January 29, 2026
概括
预后营养指数 (PNI) 和全身免疫炎症指数 (SII) 可以预测卵巢癌的生存率. 手术后较高的PNI和较低的SII表明更好的结果,有助于风险分层.
科学领域:
- 妇科瘤学 妇科瘤学
- 手术瘤学手术瘤学
- 免疫营养 免疫营养 免疫营养
背景情况:
- 卵巢癌是一种高度致命的妇科恶性瘤.
- 主体免疫营养状况和全身炎症影响手术结果.
- 预后营养指数 (PNI) 和全身免疫炎症指数 (SII) 是关键指标.
研究的目的:
- 评估皮质卵巢癌患者接受初级脱皮手术的PNI和SII的预后价值.
- 评估术前和术后PNI和SII与生存结果的关联.
主要方法:
- 78名卵巢上皮癌患者的回顾性研究.
- 术前和术后PNI和SII的计算.
- 使用相关性和回归模型分析与炎症标志物和整体存活率 (OS) 的关联.
主要成果:
- 术后PNI显著下降,而SII显著增加.
- 较低的术后PNI和较高的术前SII与炎症增加相关.
- 较高的术后PNI和较低的术前SII独立预测了改善的OS.
结论:
- 手术后的PNI和手术前的SII为卵巢癌手术提供了独立的预后信息.
- 这些指数可能有助于术后风险分层.
- PNI和SII代表了未来治疗干预的潜在目标.
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