表体转录组满足非编码RNA:m6A介导的调节在瘤发生和治疗
Prasanna Srinivasan Ramalingam1, Mokhtar Rejili2, Faouzi Haouala2
1Protein Engineering Lab, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Frontiers in cell and developmental biology
|January 29, 2026
概括
N6-甲基氨酸 (m6A) 修改是癌症中RNA代谢的关键调节者. 它们与非编码RNAs (ncRNAs) 的相互作用影响瘤进展和耐药性,提供新的治疗点.
科学领域:
- 史诗转录组学 史诗转录组学
- 癌症生物学 癌症生物学
- 在RNA代谢过程中.
背景情况:
- N6-甲基氨酸 (m6A) 修饰是RNA处理的关键表观遗传调节剂.
- m6A影响基因表达,影响瘤发生,转移和治疗耐药性.
- 在癌症中,m6A与非编码RNAs (ncRNAs) 之间的相互作用越来越被认可.
研究的目的:
- 审查m6A修饰在癌症生物学中的多方面的作用.
- 为了阐明m6A和ncRNAs (miRNAs, lncRNAs, circRNAs) 之间的复杂交叉.
- 探索针对精密瘤学的ncRNA-m6A相互作用的治疗潜力.
主要方法:
- 文献综述综合了关于癌症m6A修饰和ncRNAs的当前研究.
- 对m6A对RNA稳定性,翻译和转录结果的影响的分析.
- 检查m6A机器和ncRNAs之间的相互调节机制.
主要成果:
- m6A的修饰调节瘤基因和瘤抑制剂的转录,促进癌症的特征.
- m6A影响ncRNA生物发生,稳定性和功能,创建反循环.
- ncRNA-m6A交叉对瘤微环境,免疫反应和耐药性产生影响.
结论:
- m6A和ncRNA之间的相互作用是癌症进展和治疗耐药性的关键驱动因素.
- 针对这些相互作用为新型癌症疗法提供了有希望的途径.
- 需要进一步的研究来将这些发现转化为精密瘤学的临床应用.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
02:24Regulation of Expression Occurs at Multiple Steps
26.4K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K
02:22Regulated mRNA Transport
7.0K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
7.0K
02:36RNA Polymerase II Accessory Proteins
11.0K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
11.0K
01:46Epigenetic Regulation
33.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
01:32RNA Splicing
60.6K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.6K