在正在接受冠状动脉生理学诊断研究的稳定患者中,基于体重的固定的对氨酸剂量
Kristoffer Ken Ralota1, Deniz Tuncer1, Nay Min Htun1
1Department of Cardiology, Peninsula Health, Frankston 3199, Victoria, Australia.
World journal of cardiology
|January 29, 2026
概括
一定5000 IU的未分离氨酸 (UFH) 剂量对于诊断冠状动脉生理学程序是安全的. 这种方法简化了工作流程,与基于体重的UFH相比,没有增加出血或血栓塞栓风险.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 血管医学 血管医学
背景情况:
- 对于诊断冠状动脉生理学程序的最佳未分离氨酸 (UFH) 剂量仍然不清楚.
- 基于体重的剂量是穿皮冠状动脉干预的标准,但固定的剂量可以简化工作流程.
研究的目的:
- 为了比较固定剂量 (5000 IU) 和基于体重的UFH之间的出血和血栓栓塞结局.
- 评估固定剂量UFH在冠状动脉生理诊断程序中的安全性和实用性.
主要方法:
- 对128名接受分数流储备或微血管检测的患者进行了回顾性研究.
- 患者接受固定剂量 (5000 IU) 或基于体重 (70-100 IU/kg) 的UFH.
- 主要结局:血栓栓塞事件的组合 (辐射动脉封闭,中风,心肌梗塞). 二次结果:出血 (根据BARC标准).
主要成果:
- 在这两组中都没有发生血栓塞栓事件.
- 15%的患者出现出血 (BARC 1-2),固定剂量 (15%) 和体重 (12%) 的UFH组之间没有显著差异 (P=0.47).
- 血流与患者特征或程序因素之间没有显著的关联. 平均住院时间为1天.
结论:
- 一定5000 IU的UFH治疗方案是用于冠状动脉生理诊断程序的基于体重的剂量安全和实用的替代方案.
- 需要进行更大规模的前性研究来证实这些发现.
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