每个单基因的疾病和复杂的特征效应大小在欧洲人群中主要依赖非洲MAF

概括

非洲小等位基因频率 (MAF) 比欧洲MAF更好地预测欧洲人群中的遗传效应大小. 这一发现通过结合祖先的MAF数据,提高了对疾病遗传性和多基因风险预测的理解.

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