表观遗传g预测认知衰老和发病性痴呆症在老年人的多样化,全国代表性样本中
medRxiv : the preprint server for health sciences
|January 29, 2026
概括
表观遗传g,DNA甲基化标记,预测认知功能和降低痴呆风险. 这种基于血液的生物标志物对不同人群的早期风险评估具有前途.
科学领域:
- 遗传学和表观遗传学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 构成了重大的公共卫生挑战.
- 现有的DNA甲基化 (DNAm) 生物标志物,如GrimAge和PhenoAge,并没有被优化为预测认知衰退.
- 表观遗传g,一种新的DNAm衍生指数的一般认知能力,需要在不同的人群中进行评估.
研究的目的:
- 评估表观遗传g作为一种基于血液的认知功能和痴呆风险的生物标志物.
- 评估表观遗传g在美国种族和社会经济多样化的队列中的预测价值.
- 为了确定表观遗传学g是否在已确定的风险因素之外增加了预测价值.
主要方法:
- 利用了来自健康和退休研究 (HRS) 静脉血液研究 (N=3575) 的数据.
- 使用认知状态电话访谈 (TICS) 计算了表观遗传g分数和测量认知功能.
- 评估了6年间发生的痴呆症风险,并对人口统计,教育,APOE ε4和神经退行症标志物进行了调整.
主要成果:
- 更高的表观遗传g与更好的基线和当前认知功能有显著的关联.
- 每增加1个单位的表观遗传g预测了痴呆的6年风险降低29%.
- 在调整人口统计,社会经济因素,APOE ε4和神经病理后,关联仍然很重要.
结论:
- 表观遗传g是一种可扩展的,基于血液的认知功能和痴呆风险的标志物.
- 它提供了超越传统风险因素和神经病理学的预测价值.
- 在多样化的队列中验证支持其早期风险分析和认知衰老研究的潜力.
相关概念视频
Epigenetic Regulation
33.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
Epigenetic Regulation
3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.9K
Dementia
571
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
571
The Representativeness Heuristic
16.8K
The representative heuristic describes a biased way of thinking, in which you unintentionally stereotype someone or something. For example, you may assume that your professors spend their free time reading books and engaging in intellectual conversation, because the idea of them spending their time playing volleyball or visiting an amusement park does not fit in with your stereotypes of professors.
16.8K
Prevalence and Incidence
1.8K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.8K
Revisionist Views of Adolescent and Adult Cognition
303
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
303


