相关实验视频
Updated: Jan 30, 2026

08:22
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
15.7K
有或没有血栓切除术的大血管封闭中的 Tenecteplase:一个元分析
Ahmed Alkhiri1, Aser F Alamri1, Fahad Alturki1
1Neuroscience Center of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Frontiers in neurology
|January 29, 2026
概括
甲可改善大血管封闭性中风患者的结局,特别是当在内血管血栓切除术 (EVT) 之前在4.5小时内给予时. 扩展窗口与神经成像的使用对于没有EVT访问的选定患者是有益的.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 紧急医疗 紧急医疗
背景情况:
- 大血管封闭 (LVO) 卒中治疗正在发展,与Tenecteplase获得引力.
- 关于最佳使用Tenecteplase的不确定性仍然存在,特别是在内血管血栓切除术 (EVT) 或没有内血管血栓切除术 (EVT) 的LVO患者的桥梁治疗和延长窗口.
研究的目的:
- 系统地审查随机临床试验 (RCT) 对LVO患者的Tenecteplase使用的数据.
- 根据EVT状态和治疗窗口 (≤4.5小时与>4.5小时) 评估结果.
主要方法:
- 系统审查涉及使用或不使用Tenecteplase治疗的LVO患者的RCT.
- 根据EVT状态和治疗窗口分析的结果.
- 使用修改的兰金尺度 (mRS) 轮班分析 (gORs) 评估的残疾减少.
- 使用风险比率 (RRs) 分析的功能独立,优异的结果,死亡率和症状性内出血 (sICH).
主要成果:
- 乙烯基的使用与较大的残疾减少 (gOR,1.19) 和改善的功能独立性 (RR,1.14) 与没有血栓溶解有关.
- 在sICH (RR, 1.46) 或死亡率 (RR, 1.07) 中没有发现显著差异.
- 在4.5小时内服用tenecteplase改善了EVT前的结果;在EVT后4.5小时后没有发现任何好处.
- 在EVT不合格的LVO患者中,Tenecteplase在4.5小时后改善了EVT不合格的LVO患者的结局,这些患者在CT输液上有可挽救的组织.
结论:
- 静脉注射的Tenecteplase改善了LVO患者的治疗结果.
- 当在EVT之前在4.5小时内服用时观察到的好处.
- 延长窗口 Tenecteplase,以神经成像为指导,有利于没有EVT访问的选定患者.
相关概念视频
Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Structure of Blood Vessels
9.4K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
9.4K
Anatomy of Blood Vessels
2.7K
The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta,...
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta,...
2.7K
Development of Blood Vessels
1.4K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
1.4K
Overview of Blood Vessels
10.5K
The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
10.5K
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H
6.7K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.7K

