相关实验视频
Updated: Jan 30, 2026

05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
648
在全身性红斑狼中用氧化和阿尼弗洛卢马布进行无葡萄糖皮质激素诱导疗法:一个病例报告
Mitsuki Tezuka1, Shimoyama Shuhei1, Masanari Sugawara1
1Department of Rheumatology, Obihiro-Kosei General Hospital, Obihiro, JPN.
Cureus
|January 29, 2026
概括
一名患有系统性红斑狼 (SLE) 的患者在没有使用葡萄糖皮质类药物 (GCs) 的情况下使用氧化和anifrolumab实现了疾病控制. 这一案例凸显了无GC诱导疗法的潜力,用于管理SLE爆发.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病.
- 在SLE中长期使用葡萄糖皮质激素 (GC) 具有重大风险.
- 对SLE的无GC诱导疗法仍然是一个临床挑战.
研究的目的:
- 介绍一个成功的SLE无GC诱导疗法的案例.
- 评估氧化 (HCQ) 和阿尼弗罗卢马布 (ANI) 在治疗SLE爆发中的疗效.
- 探索ANI在SLE无GC治疗策略中的潜力.
主要方法:
- 一名患有SLE的60岁女性患者接受了治疗.
- 最初的治疗包括HCQ.
- 由于对HCQ的反应不足,Anifrolumab (ANI) 被顺序添加.
主要成果:
- 患者通过添加ANI,实现了发烧的快速缓解和血液细胞计数的改善以及皮疹严重性的改善.
- 在整个治疗过程中,成功避免了GC.
- 他们被诊断为II类狼性炎和死角性淋巴腺炎.
结论:
- 使用HCQ和ANI的无GC诱导疗法可以有效地管理SLE.
- 阿尼弗罗卢马布显示出作为SLE的关键治疗剂的承诺,使GC的中止成为可能.
- 这个案例支持探索SLE管理的无GC方法.
相关概念视频
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.6K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.6K
Data Reporting and Recording
5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
485
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
485
Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Types of Reports I: Hands-off Report
1.5K
A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Second Order systems II
406
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
406

