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来自一种新型CTLA-4哈普洛缺陷变异的免疫调节障碍

Nina N Brodsky1, Alan Kennedy2, Daniel Glaser1

  • 1Department of Pediatrics, Pediatric Genomics Discovery Program, Yale University School of Medicine, New Haven, CT, USA.

Journal of human immunity
|January 29, 2026
PubMed
概括

细胞毒性T淋巴细胞抗原4 (CTLA-4) 的新型变异损害了其稳定性和功能,导致多代家庭的免疫失调和自身免疫. 这一发现扩大了对CTLA-4哈普洛缺陷 (CHAI) 的理解.

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