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相关概念视频

Dosage Compensation02:50

Dosage Compensation

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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will...
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Overview
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Protein Folding01:25

Protein Folding

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
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Compensation Mechanisms01:28

Compensation Mechanisms

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The human body employs intricate mechanisms to counteract changes in blood pH, preventing conditions like acidosis (pH < 7.35) and alkalosis (pH > 7.45). These compensatory responses aim to restore normal arterial blood pH by engaging respiratory or renal systems, depending on the source of the imbalance.
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This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH...
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Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
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The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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相关实验视频

Updated: Jan 30, 2026

Visualization of Cortical Modules in Flattened Mammalian Cortices
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补偿皮层厚度用于皮层折叠相关的变化.

Nagehan Demirci1, Timothy S Coalson2, Maria A Holland3

  • 1Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States.

Imaging neuroscience (Cambridge, Mass.)
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概括

这项研究引入了一种新方法,通过消除折叠变异来准确测量大脑皮层厚度. 这提高了用于健康和疾病研究的大脑成像生物标志物的可靠性.

关键词:
人类连接体项目 人类连接体项目皮层缩 皮层缩皮质的折叠 皮质的折叠皮层厚度 皮层厚度曲线的曲率是因为个体的变化,个体的变化.

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科学领域:

  • 神经成像是一种神经成像.
  • 大脑形态学 大脑形态学
  • 计算神经科学是一种神经科学.

背景情况:

  • 皮层厚度是一个关键的大脑生物标志物,但受当地皮层折叠的影响.
  • 现有的折叠补偿方法不完整或降低空间精度.
  • 皮层折叠的个体变化将噪声引入厚度测量.

研究的目的:

  • 开发和验证一种用于折叠补偿皮质厚度估计的新方法.
  • 为了提供一个更生物可解释的皮质结构的尺度.
  • 提高皮层厚度作为结构表型的实用性.

主要方法:

  • 开发了一种使用非线性局部多重回归与五个折叠测量的新方法.
  • 模拟并从皮质厚度测量中删除与折叠相关的差异.
  • 将该方法应用于人类结合体项目 (HCP-YA和HCA) 数据集.

主要成果:

  • 证明了区域内和个体间的变异性大幅减少.
  • 年龄对皮质厚度的标准化效应大小增加了41%.
  • 保持神经生物学预期的模式和空间精度,与空间平滑不同.

结论:

  • 新方法提供了更准确和可解释的皮质厚度测量.
  • 这种技术可以提高皮质厚度,作为大脑健康和疾病的生物标志物.
  • 该方法被整合到HCP管道中,以便在神经科学研究中得到更广泛的应用.