通过外围神经介导降低葡萄糖:机制,转化策略和未来前景
Shuai-Yan Wang1, Xin Liu1, Zi-Mu Li1
1Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
World journal of diabetes
|January 29, 2026
概括
周围神经系统 (PNS) 调节葡萄糖的平衡. 本综述探讨了PNS介导的降糖策略,为糖尿病和相关代谢障碍的新型无药疗法提供了路线图.
科学领域:
- 神经科学是一个神经科学.
- 代谢科学 代谢科学
- 内分泌学 在内分泌学.
背景情况:
- 葡萄糖平衡对于代谢健康至关重要,其破坏会导致高血糖症 (如糖尿病) 或低血糖症.
- 这些情况会导致严重的并发症,包括病,神经病和心血管疾病.
- 周围神经系统 (PNS) 是通过神经回路影响关键代谢器官的葡萄糖平衡的研究不足的调节器.
研究的目的:
- 综合PNS介导的降血糖机制和途径的最新进展.
- 审查失糖症的转化干预措施,包括基于设备的神经调节和再生策略.
- 为开发用于葡萄糖失调的新型无药疗法提供路线图.
主要方法:
- 关于PNS和葡萄糖恒温的临床前和临床研究的综合文献综述.
- 对参与葡萄糖调节的特定器官神经通路的分析.
- 评估各种转化干预措施,包括神经调节和闭环系统.
主要成果:
- PNS通过同情神经,副同情神经,感觉神经和体神经在葡萄糖稳定中发挥着重要作用.
- PNS与肝脏,胰腺和肠道等器官之间的相互作用对于血糖控制至关重要.
- 新兴的干预措施显示出无毒药物治疗失糖症的前景.
结论:
- PNS为管理葡萄糖平衡的新型治疗策略提供了一个有希望的目标.
- 需要进一步的研究和临床转化,才能充分利用PNS介导的降血糖.
- 开发治疗失糖症的无药疗法是未来的一个关键方向.
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