尼尔马特雷尔维尔/里托纳维尔的使用降低了免疫缺陷患者长期COVID的风险
Karen M Gilbert1, Mostafa Aglan2, Aditi Jogdand3
1Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
概括
急性尼尔马特里尔维尔/里托纳维尔使用降低了长期COVID的风险在免疫功能低下的患者. 需要进一步的临床试验来证实这些发现,在这个脆弱的群体.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- SARS-CoV-2 感染的急性后续症状,或长期COVID,对全球健康构成重大挑战.
- 免疫功能受损的个体面临更高的严重COVID-19风险和可能更糟糕的长期COVID结果.
- 正在研究抗病毒疗法,以了解它们在缓解长期COVID发展方面的潜力.
研究的目的:
- 评估急性涅马特里尔维尔/里托纳维尔治疗在减少长期COVID的发生率方面的有效性.
- 评估涅马特里尔维尔/里托纳维尔对长期COVID风险的影响,特别是在免疫功能低下的患者队列中.
主要方法:
- 追溯队列研究的设计.
- 对被诊断患有SARS-CoV-2感染的患者的电子健康记录进行分析.
- 在接受急性尼尔马特里尔维尔/里托纳维尔和未接受急性尼尔马特里尔维尔/里托纳维尔的患者之间,长期COVID发病率的比较,重点是免疫受损的个体.
主要成果:
- 急性尼尔马特里尔维尔/里托纳维尔的使用与显著降低患长期COVID的风险有关.
- 在免疫缺陷患者的亚组中观察到这种保护作用.
- 在长期COVID预防的背景下,没有突出与nirmatrelvir/ritonavir相关的重大不良事件.
结论:
- 急性涅马特里尔维尔/里托纳维尔治疗可能是一个可行的策略,以减少长期COVID的负担,特别是在免疫功能低下的人群中.
- 这些发现强调了将免疫功能受损的患者纳入未来抗病毒干预临床试验的重要性.
- 需要进一步的前性研究来证实这些结果并阐明底层机制.
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