父亲的微塑性暴露会改变精子小非编码RNA,并影响小鼠后代代代谢健康
Seung Hyun Park1, Jianfei Pan1, Xudong Zhang2
1Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA.
Journal of the Endocrine Society
|January 29, 2026
概括
父亲暴露于微塑料 (MPs) 影响后代的代谢健康,导致性别特异的肥胖和小鼠的胰岛素抵抗. 精子小非编码RNA可能会调解这些代际效应.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 代谢性疾病 代谢性疾病
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,具有潜在的人类健康风险.
- 人类暴露于MPs是普遍存在的,MPs在生殖组织中被发现.
- 父母接触污染物可能会影响后代的心脏代谢健康,但不清楚MP的影响.
研究的目的:
- 为了研究父性微塑料暴露对小鼠F1后代代代谢健康的影响.
- 探索精子小非编码RNAs (sncRNAs) 在调解代际效应中的作用.
主要方法:
- 小鼠通过父亲的方式接触到微塑料.
- 评估了后代的代谢健康状况,包括饮食引起的肥胖和胰岛素抵抗.
- 使用PANDORA-seq.分析了精子sncRNA配置文件.
- 在体外实验中评估了sncRNAs对基因表达的影响.
主要成果:
- 父亲的MP暴露导致后代体质的性别特异变化和饮食诱导的肥胖.
- 暴露于MP的的雌性后代表现出严重的胰岛素耐药性.
- 暴露于MP改变了精子tsRNA和rsRNA配置文件.
- 特定的MP改变的sncRNAs影响了小鼠胚胎干细胞中的基因表达.
结论:
- 父亲接触微塑料可能对后代代代谢健康产生不利的代际影响.
- 精子sncRNAs是这些由父亲获得的心脏代谢疾病的潜在媒介.
- 需要进一步的研究来了解塑料暴露对人类的健康后果.
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