基于米托米辛C的高热性腹腔内化疗改善了腹腔内转移的结肠直肠癌患者的生存率
Chayanit Sirisai1, Hathaiwan Moungthard1, Kitinut Timudom1
1Division of Gastrointestinal and Liver Clinic, Department of Surgery, National Cancer Institute of Thailand, Bangkok, THA.
Cureus
|January 29, 2026
概括
基于米托米辛C (MMC) 的高热性腹腔内化疗 (HIPEC) 显著改善了腹腔内转移的结直肠癌患者的存活率. 与标准护理相比,这种局部区域治疗提供了生存益处.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 与腹转移的预后不好.
- 超热腹内化疗 (HIPEC) 的目的是消除腹癌细胞.
- 这项研究评估了基于米托米辛C (MMC) 的HIPEC用于CRC腹膜转移.
研究的目的:
- 评估基于MMC的HIPEC在患有腹膜转移的CRC患者的疗效.
- 评估HIPEC的安全性和瘤结果.
- 将HIPEC与非HIPEC管理进行比较,以了解生存益处.
主要方法:
- 对48名患有腹膜转移的CRC患者的回顾性审查 (2018年11月 - 2024年1月).
- 进行细胞减小手术 (CRS) 的患者与基于MMC的HIPEC和没有HIPEC的患者之间的比较.
- 对临床病理学,外科及瘤学结果的分析.
主要成果:
- 在93.5%的HIPEC患者中实现了完整的细胞减少 (CC0).
- 术后并发症发生在20.8%的患者中,其中8.3%的患者需要因静脉泄漏而重新手术.
- 在HIPEC组中,平均整体存活时间明显更长 (54.2个月与24.5个月).
- 五年整体存活率为47.9%与HIPEC相比4.9%没有.
- 在HIPEC之后,无进展生存时间的中位数为29.6个月.
结论:
- 结合CRS和基于MMC的HIPEC,为某些患有腹膜转移的CRC患者提供了显著的生存优势.
- 基于MMC的HIPEC是这个患者群体的有效地方区域治疗策略.
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