用Paxlovid治疗的COVID-19患者的心血管结果:一个多中心回顾性研究
Wei-Lun Chen1, Victor Chien-Chia Wu1,2, Chun-Li Wang1,2
1Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center.
Acta Cardiologica Sinica
|January 29, 2026
概括
帕克斯洛维德 (nirmatrelvir-ritonavir) 改善了COVID-19患者的短期生存,但增加了静脉血栓栓塞的风险. 仔细监测和选择患者至关重要,特别是对于心血管疾病患者.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于COVID-19的流行,人们迅速开发了像Paxlovid这样的治疗方法,这是一种口服抗病毒药物.
- 虽然对高危人群有效,但Paxlovid对心血管的影响需要进一步调查.
- COVID-19本身带来了显著的心血管风险,使治疗评估复杂化.
研究的目的:
- 评估COVID-19患者与Paxlovid治疗相关的心血管结果和死亡率.
- 评估Paxlovid对心血管事件和生存的短期和长期影响.
主要方法:
- 使用台湾长光纪念医院系统 (2022年1月至12月) 的数据进行了回顾性队列研究.
- 倾向性得分匹配创建了可比较的组:606名用Paxlovid治疗的患者和1,809名未接受治疗的患者.
- 主要结局包括12个月的随访期间心血管事件和全因死亡率.
主要成果:
- 帕克斯洛维德在COVID-19感染后3个月和6个月显著降低了全因死亡率.
- 这种生存益处在12个月的随访中没有持续.
- 静脉血栓栓塞率在6个月和12个月后在Paxlovid组显著更高.
结论:
- 帕克斯洛维德为COVID-19患者提供短期生存优势.
- 用Paxlovid的治疗与静脉血栓栓塞并发症的风险增加有关.
- 仔细的患者选择和监测是必不可少的,特别是对于具有先前心血管疾病的人来说.
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