儿童肥胖和维生素D缺乏之间的相互作用:机制和影响
Xiao Zhou1, Yuhe Chen1, Jianxin Xu1
1Department of Pediatrics, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.
Frontiers in pediatrics
|January 29, 2026
概括
儿童肥胖和维生素D缺乏 (VDD) 创造了一个有害的循环. 维生素D补充剂在特定情况下有利于胰岛素敏感性和血压,但肥胖儿童需要更高的剂量才能产生潜在的影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 儿童肥胖和维生素D缺乏 (VDD) 是全球重要的健康问题.
- 这些情况相互加剧,导致超越骨和代谢健康的后果.
- 肥胖可以通过像体积稀释和肝功能受损等机制驱动VDD.
研究的目的:
- 审查儿童肥胖和VDD之间的相互作用的证据.
- 分析维生素D补充剂在肥胖儿童中的疗效.
- 确定影响维生素D状态和补充反应的因素.
主要方法:
- 综合了十年的临床,翻译和门德尔随机化证据.
- 对12项涉及1538名参与者的随机试验的元分析.
- 检查诸如基线维生素D水平,炎症和遗传标记等因素.
主要成果:
- 维生素D补充剂改善了胰岛素敏感性,并在基线25-氧维生素D (25(OH) D<20 ng/mL时降低了缩血压,并且炎症很小.
- 随着补充,没有观察到BMI或脂肪质量的持续减少.
- 肥胖儿童需要更高的维生素D剂量 (2-3倍标准) 来达到目标水平,在炎症存在时,益处会稳定和减少.
结论:
- 在儿童肥胖和VDD之间存在一个自我延续的循环.
- 目前的维生素D补充策略可能对肥胖儿童来说不足.
- 对于这一群体,需要精确剂量算法和对最佳补充剂的进一步研究.
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