怀孕期间母亲焦虑/抑郁症与后代湿疹/AD发展之间的关联:基于队列研究的元分析
Mengjiao Yu1, Qiufeng Zhang2, Junyi Chen2
1Emergency Medical Center, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, Ningbo, Zhejiang, China.
Frontiers in pediatrics
|January 29, 2026
概括
孕妇在怀孕期间的抑郁和焦虑与儿童患湿疹和皮炎 (AD) 的风险更高有关. 这种关联在各种子组和地理区域中观察到,突出显示了产前心理健康的重要性.
科学领域:
- 围产期心理健康研究
- 儿科皮肤病学和免疫学
- 关于慢性疾病发展的流行病学研究.
背景情况:
- 产前暴露于母亲的精神健康状况,如焦虑和抑郁症,是一个日益关注的问题.
- 母亲心理痛苦对后代免疫系统发育和随后的皮肤状况的潜在影响需要彻底调查.
- 了解这些关联可以为危险怀孕提供有针对性的干预措施.
研究的目的:
- 进行一项元分析,调查怀孕期间母亲焦虑/抑郁症与后代湿疹/皮炎 (AD) 发病率之间的联系.
- 探索潜在的改变因素,如地理区域和暴露的三个月.
- 综合现有队列研究的证据,以提供风险的综合估计.
主要方法:
- 在PubMed,科学网,Embase和Cochrane图书馆进行了系统的文献搜索.
- 包括的研究是母体抑郁症或焦虑症在怀孕期间被医生诊断或通过标准化天平评估的队列研究.
- 评估的主要结果是后代中湿疹或AD的发病率,并使用几率比率 (OR) 和置信区间 (CI) 进行了聚合分析.
主要成果:
- 孕期产妇抑郁 (OR=1.06,95%CI=1.01-1.11) 和焦虑 (OR=1.11,95%CI=1.03-1.19) 与后代湿疹/AD发病率较高有关.
- 亚组分析表明,在东方 (OR=1.13) 和西方 (OR=1.34) 国家的后代中,AD与母亲焦虑 (OR=1.24) 的发病率较高,疹/AD增加.
- 当母亲焦虑在第一个 (OR=1.13) 或第二个 (OR=1.25) 妊娠季度被确定时,以及第二个妊娠季度的母亲抑郁症 (OR=1.30) 时,这种联系更为明显.
结论:
- 孕妇在怀孕期间的抑郁和焦虑可能与后代患湿疹和皮炎的风险增加有关.
- 这些发现强调了考虑母亲心理健康的重要性,作为这些常见的儿童皮肤疾病发展的一个因素.
- 进一步的研究可能将重点放在潜在的生物机制和预防策略上.
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