在早期乳腺癌幸存者中,经过16周的社区运动训练后,急性运动诱导的甲基胺反应
Jeb F Struder1, Aiden J Chauntry1, Lauren C Bates-Fraser1,2,3
1Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
乳腺癌幸存者 (BCS) 和对照人群表现出类似的运动诱导的甲醇胺反应,即使在训练后. 这表明其他因素有助于在BCS运动后的免疫细胞恢复.
科学领域:
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
- 癌症的生存率 癌症的生存率
背景情况:
- 乳腺癌幸存者 (BCS) 运动后表现出免疫细胞调动减少,这部分恢复与训练.
- 上腺素 (EPI) 和上腺素 (NE) 调节免疫功能,对运动有反应性,但它们在BCS免疫恢复中的作用尚不清楚.
- 之前的研究指出,在运动后的BCS中,catecholamine反应减弱,但这在训练状态下没有研究过.
研究的目的:
- 为了比较BCS中的急性运动和运动干预之前和之后的对照中对catecholamine反应的反应.
- 为了确定运动训练是否能在BCS中使运动诱导的甲醇胺反应正常化.
主要方法:
- 13个BCS和13个控制器 (CON) 在60%的峰值功率输出时经历了45分钟的循环.
- 血液样本在基线,运动后立即和运动后1小时分析EPI和NE水平.
- 测量是在16周社区运动计划之前 (PRE) 和之后 (POST) 进行的.
主要成果:
- 无论BCS和CON都显示了运动后PRE的EPI和NE增加,没有群体差异.
- 在POST干预后,尽管BCS和CON之间存在不同的趋势,但在NE启动方面没有发现显著的群体差异.
- 对于NE恢复或EPI反应 (启动或恢复) POST.没有观察到群体差异.
结论:
- 无论训练状态如何,BCS和CON都表现出类似的运动诱导的甲醇胺反应.
- 这些发现表明,除了甲基胺信号传递之外的其他机制可能对BCS中观察到的训练诱导的免疫细胞恢复更有影响.
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