肥胖和结直肠癌风险:系统审查和元分析
Lachlan James Chun-Lok Leung1, Rohan Sharad Sharma2, Brandon Cheng2
1School of Medicine and Dentistry, Griffith University, Gold Coast 4215, Queensland, Australia. leunglachlan@gmail.com.
World journal of clinical oncology
|January 29, 2026
概括
肥胖显著增加了男性和女性结直肠癌 (CRC) 的风险. 保持健康的体重指数 (BMI) 对于CRC预防策略至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肥胖 (BMI ≥30 kg/m2) 与增加结直肠癌 (CRC) 风险有关.
- 近几十年来,尽管全球肥胖率不断上升,但数据有限.
- 更新的生物机制和环境因素需要对肥胖和CRC关系进行审查.
研究的目的:
- 为了确定肥胖和CRC风险之间是否存在更新的相关性.
- 综合最近关于肥胖和CRC发病率的数据.
主要方法:
- 使用聚合估计效应评估了最近的观察性研究.
- 对来自PubMed,EMBASE,Scopus和Cochrane数据库的数据进行了性别分层的元分析.
- 对不适合进行元分析的研究进行了定性分析.
主要成果:
- 在83,506名参与者中,在男性 (HR: 1.71,95% CI: 1.44-2.02) 中发现了肥胖和CRC发病率之间的显著正相关性.
- 在152,043名参与者的女性中也观察到正相关性 (HR:1.26,95% CI:1.03-1.53).
- 对所有研究的定性分析始终支持肥胖和两性CRC之间的积极关联.
结论:
- 肥胖 (BMI ≥30 kg/m2) 与健康的BMI相比,显著增加了CRC风险.
- 强调预防肥胖的重要性,作为减少CRC发病率的可修改风险因素.
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