相关实验视频
Updated: Jan 30, 2026

11:37
In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
Published on: February 18, 2015
14.2K
基塔-九州肺癌抗原-1表达在最初的胃瘤预测多种癌症的发展:一个试点研究
Nobue Futawatari1,2, Takashi Fukuyama3, Yusuke Akimoto2
1Department of Surgery, National Hospital Organization Sagamihara National Hospital, Sagamihara 252-0395, Kanagawa, Japan.
World journal of clinical oncology
|January 29, 2026
概括
在初始的胃瘤中,特别是中胃和下胃的基塔-九州肺癌抗原-1 (KK-LC-1) 表达与发展多种胃癌有关. 这一发现表明,KK-LC-1可能预测未来的多重GC发育.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 基塔-九州肺癌抗原-1 (KK-LC-1) 经常被表达为胃癌 (GC).
- 之前的研究指出,多个GC患者的KK-LC-1阳性高.
- KK-LC-1在预测多个GC发展中的作用需要进一步调查.
研究的目的:
- 探索KK-LC-1作为生物标志物的临床实用性,用于识别患有多种胃癌风险的患者.
- 调查KK-LC-1表达在初始瘤病变和多个GCs的发展之间的关联.
- 分析KK-LC-1表达与临床病理特征相关的初步队列.
主要方法:
- 免疫组织化学被用来评估KK-LC-1表达在109个GC患者 (82个单一,27多种癌症).
- 使用费舍尔的精确测试分析了临床病理相关性.
- 瘤位置被分类,专注于最初的癌症部位.
主要成果:
- 在胃中部和下部,KK-LC-1表达与年龄较大,细分组织学和多个GC相关.
- 所有患有多个GC的患者 (100%) 显示KK-LC-1-阳性初始病变.
- 在初始瘤中,KK-LC-1阳性在多种癌症 (中/下胃) 中明显高于单一癌症.
结论:
- 在初始胃瘤中,特别是中胃和下胃的KK-LC-1表达可能预测多个GC的未来发展.
- 在单独的瘤 (中/下胃) 中缺少KK-LC-1可能表明后续多种原发性癌症的风险较低.
- KK-LC-1显示出作为多种胃癌发展的预测生物标志物的潜力.
相关概念视频
Cancer Stem Cells and Tumor Maintenance
6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Predicting Products: SN1 vs. SN2
17.3K
Nucleophilic substitution reactions of alkyl halides can proceed via an SN1 or an SN2 mechanism. While in SN2 reactions, the nucleophile attacks the substrate simultaneously as the leaving group departs, in SN1 reactions, the substrate first dissociates to give the carbocation intermediate. Various factors such as the structure of the substrate, the strength of the nucleophile, and the nature of the solvent promote one mechanism over the other.
With increased substitution on the alkyl halide,...
With increased substitution on the alkyl halide,...
17.3K
Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Cancer-Critical Genes II: Tumor Suppressor Genes
9.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K
Regulation of Expression Occurs at Multiple Steps
26.4K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K
Cancer
54.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.2K

