心率变化反映了克罗恩病患者内镜活动和全身炎症
Ruohan Wang1, Fengfeng Yan2, Hongjie Zhang3
1Department of Infectious Disease and Liver Disease, The Second Hospital of Nanjing, Nanjing, China.
Frontiers in medicine
|January 29, 2026
概括
心率变化 (HRV) 在活跃的克罗恩病 (CD) 患者中显示了降低的副交感活动. HRV参数与疾病活性和炎症相关,提供了一个非侵入性评估工具.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 自主神经科学 自主神经科学
背景情况:
- 自主神经系统 (ANS) 功能障碍在克罗恩病 (CD) 中得到了认可.
- 心率变化 (HRV) 是一种非侵入性测量ANS活动的方法.
- 了解HRV和CD活动之间的联系至关重要.
研究的目的:
- 研究CD患者HRV参数与疾病活性之间的关系.
- 探索HRV指标和系统性炎症生物标志物之间的相关性.
- 开发基于HRV的模型,用于评估CD的内镜疾病活性.
主要方法:
- 84名CD患者 (44名活跃,40名缓解) 接受HRV测试和内镜检查.
- 收集了临床,人口和实验室数据.
- 使用了二进制逻辑回归和名ogram模型.
主要成果:
- 与缓解期患者相比,活跃的CD患者的LF/HF比率显著更高,SDNN和HF较低.
- SDNN和HF与CD的简单内镜评分 (SES-CD) 有负相关性.
- HR和LF/HF是内镜活动的独立风险因素;建立了一个预测模型 (C指数:0.803).
结论:
- 活性CD与降低的副交感活动有关,如HRV所示.
- HRV参数反映了CD的内镜性疾病活动和系统性炎症.
- HRV具有作为全面CD评估的非侵入性工具的潜力.
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