诊断时EVI1的低表达标识了成年Ph-负B细胞急性淋巴细胞白血病的高风险亚组
Shu Kong1, Xu Wang1, Wen-Min Chen1
1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China.
Frontiers in medicine
|January 29, 2026
概括
成年B细胞急性淋巴细胞白血病 (B-ALL) 中EVI1表达低表明预后较差. 这一发现有助于对具有特定融合基因的患者的风险分层进行细化.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 在B细胞急性淋巴细胞白血病 (B-ALL) 中EVI1表达的预后意义尚不清楚.
- EVI1是一种涉及各种癌症的基因,但它在B-ALL预后中的特定作用需要进一步调查.
研究的目的:
- 调查成人费城染色体阴性B-ALL. EVI1转录水平的预后影响.
- 确定EVI1表达是否可以改善风险分层,特别是在由融合基因定义的子组中.
主要方法:
- 实时定量PCR用于测量436名成年Ph阴性B-ALL患者骨髓样本中的EVI1转录水平.
- 进行了统计分析,以将EVI1水平与无复发生存率 (RFS) 和总生存率 (OS) 相关联,并评估其独立的预后值.
主要成果:
- 低EVI1表达 (第三季度以下) 与整体队列中较差的RFS和OS显著相关 (分别为p < 0.0010和p < 0.0001).
- 低EVI1表达是RFS (HR 2.3) 和OS (HR 2.5) 的独立不良预后因素.
- 在特定的融合基因子组中 (TCF3::PBX1,Ph-like,MEF2D,ZNF384),低EVI1表达与较差的RFS相关或倾向于较差RFS,并在ZNF384组中较差OS.
结论:
- 诊断时低EVI1转录水平与成人Ph-负B-ALL的预后不佳有关.
- EVI1表达水平可能会增加B-ALL患者的风险分层,特别是当与特定的融合基因概况一起考虑时.
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