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Updated: Jan 30, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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在TP53突变的中枢神经系统淋巴瘤中使用CAR-T细胞疗法:克服高风险的遗传障碍

Danyang Li1, Rui Liu1, Zhonghua Fu1

  • 1Department of Lymphoma and Myeloma Research Center, Beijing GoBroad Hospital, Beijing, China.

Frontiers in medicine
|January 29, 2026
PubMed
概括

化学抗原受体T (CAR-T) 细胞疗法在中枢神经系统淋巴瘤 (CNSL) 中显示出有效性,即使在具有TP53突变的患者中也是如此. 具有TP53突变的非生殖中心B细胞样CNSL患者可能从CAR-T疗法中获益最多.

关键词:
在CART-T中,我们可以使用CAR-T.在CNSL中,CNSL是CNSL.在TME中,它是最重要的.这就是TP53的特点.细胞治疗疗法细胞治疗疗法

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