精神分裂症患者的IgG/IgM涂层肠道微生物群:与炎症疾病活动的关联
Guohao Xu1,2, Ruibin Luo3, Ze Wu1,4
1The School of Basic Medicine, Beihua University, Jilin, China.
Frontiers in psychiatry
|January 29, 2026
概括
免疫球蛋白M (IgM) 覆盖的肠道细菌在精神分裂症患者中增加,导致肠道炎症. 这些发现表明,SCZ相关的免疫失调可能存在潜在的生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 免疫球蛋白A (IgA) 是肠道免疫的关键,但免疫球蛋白M (IgM) 和免疫球蛋白G (IgG) 在宿主微生物群相互作用中的作用尚不清楚,特别是在精神分裂症 (SCZ) 中.
- 肠道失调和免疫激活与SCZ有关,但IgG/IgM涂层肠道微生物群对SCZ相关炎症和行为的具体贡献尚不清楚.
研究的目的:
- 研究SCZ患者的IgG/IgM涂层肠道微生物群的特征.
- 探索IgG/IgM涂层肠道微生物群对肠道病理,外周免疫力和小鼠模型行为的影响.
主要方法:
- 招募了患有SCZ,其他精神疾病 (OPD) 和健康对照患者.
- 使用磁激活细胞分类 (MACS) 和16SrRNA测序从便样本中分离和分析IgG/IgM涂层的肠道微生物群.
- 在具有IgG/IgM涂层肠道微生物群的小鼠中进行了便微生物群移植 (FMT),以评估对肠道和免疫参数的影响.
主要成果:
- 在SCZ患者中观察到IgM涂层细菌的比例显著更高,具有特定细菌系的丰富.
- 接受高IgM涂层细菌的小鼠显示中性粒细胞枯竭减少和轻微的肠道炎症.
- 高IgG涂层细菌,虽然SCZ下降,也诱导了肠道炎症,但在小鼠中没有观察到类似焦虑的行为.
结论:
- 覆盖IgG/IgM的肠道微生物群表现出与SCZ相关的独特的免疫反应特征.
- 这些微生物群落促进肠道炎症,但不会诱导类似焦虑的行为.
- 这些发现突出了SCZ相关的免疫失调的潜在新生物标志物和个性化治疗的目标.
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