在非补偿性肝硬化中,身体组成异常和性别特异预后之间的重叠
Jie Yang1,2, Yan Song1, Qing Liu1,2
1Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.
Frontiers in nutrition
|January 29, 2026
概括
在患有不补偿性肝硬化的患者中,身体构成概况因性别而异. 多重体质异常显著增加死亡风险,特别是在女性中,突出了需要性别特异性预后模型的需求.
科学领域:
- 医学 医学 医学 医学 医学
- 放射学 放射学是一门学科.
- 老年学是指老年学的学科.
背景情况:
- 使用计算机断层扫描 (CT) 分析体质 (BC) 分析对于了解患者健康至关重要.
- 根据性别分层的明显的BC概况可能会影响住院患者的长期结果.
研究的目的:
- 为了展示由性别分层的明显的身体组成概况.
- 澄清这些个人资料对住院患者长期死亡率的联合影响.
主要方法:
- 519名住院患者的回顾性队列研究,其中有急性去补偿发作.
- 利用CT注释的BC参数 (肉类,骨髓炎,皮下脂肪率低,内脏脂肪率高) 与性别特定的,基于结果的切断值.
- 开发了一种整合白蛋白,MELD-Na得分和重叠BC异常的诺米图,用于预后.
主要成果:
- 在BC形状中观察到显著的性别特异性变异.
- 在两性中都普遍存在高内脏脂肪;重叠的表型各不相同.
- 多重BC异常与1年全因死亡率显著增加有关,特别是在女性 (722%更高的风险).
- 诺米图表显示出中等准确性和对预后的临床益处.
结论:
- 在非补偿性肝硬化患者中,存在体质构成特征的性别特异性变异.
- 身体组成异常的重叠是死亡率的强有力的预测因素.
- 一个整合BC,白蛋白和MELD-Na的诺米图显示了改善患者预后的希望.
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