瘤微生物组-转录基因组交叉识别了Prevotella作为NSCLC中的免疫治疗预测剂
Na Wang1, Lifang Ma2, Yugang Huang3
1Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Theranostics
|January 29, 2026
概括
居住在准癌组织中的Prevotella与更好的非小细胞肺癌预后和免疫检查点抑制剂反应相关. 这一发现可能有助于开发针对个性化免疫疗法的新诊断工具.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 文字转录学 (Transcriptomics) 是一个学科.
背景情况:
- 瘤微生物组影响瘤免疫微环境,但其在非小细胞肺癌 (NSCLC) 和对免疫检查点抑制剂 (ICI) 的反应中的作用尚不清楚.
- 了解微生物与宿主相互作用对于开发有效的癌症疗法至关重要.
研究的目的:
- 研究组织内微生物群,宿主基因表达和NSCLC中的免疫治疗反应之间的关系.
- 识别与患者预后和治疗结果相关的特定微生物.
主要方法:
- 使用2bRAD-M和散装RNA测序,分析来自NSCLC患者的瘤和准癌组织样本.
- 应用条件相互信息算法来研究微生物与宿主之间的相互作用.
- 在临床队列中评估微生物与预后和治疗反应的关联.
主要成果:
- 准癌性组织的微生物多样性比瘤组织更高.
- 与PT居民Prevotella显着与改善NSCLC预后和对ICI的反应有关,与Bradyrhizobium不同.
- 一个结合PT居民Prevotella丰度和血液标志物的诊断模型在预测ICI反应方面超过了PD-L1.
结论:
- PT居民Prevotella是预测NSCLC患者的预后和ICI反应的关键生物标志物.
- 将PT-居民Prevotella与临床血液指标相结合,显示出在NSCLC中个性化免疫疗法策略的潜力.
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