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Updated: Jan 30, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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瘤细胞FAP在侵袭性局部ccRCC中协调EMT和免疫抑制

Teijo Pellinen1, Lassi Luomala2, Kalle E Mattila3,4

  • 1Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE) and iCAN - Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.

Theranostics
|January 29, 2026
PubMed
概括

在清细胞脏细胞癌 (ccRCC) 中,表达纤维细胞激活蛋白 (FAP) 的瘤细胞表明具有攻击性亚型. 这一发现将表皮细胞到介质细胞的过渡 (EMT) 与免疫抑制联系在一起,为ccRCC提供了新的生物标志物.

关键词:
在 FAP FAP 里面.清细胞细胞癌是什么?表皮细胞到介质细胞的过渡.空间性免疫抑制的作用.瘤微环境是一个微环境.

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