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Updated: Jan 30, 2026

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针对FOSL1/IKKα正反循环,通过抑制NF-κB信号,减轻质母细胞瘤的恶性病变

Beichen Zhang1,2, Hao Tian2, Haoyu Zhou1,2

  • 1Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Theranostics
|January 29, 2026
PubMed
概括

质母细胞瘤 (GBM) 的进展是由与IKKα和UCHL3的FOS样抗原1 (FOSL1) 反循环驱动的,激活NF-κB信号. 用siRNA纳米颗粒准这一轴为GBM提供了一个有前途的治疗策略.

关键词:
在FOSL1/IKKα正反循环中,在NF-κB信号传输中.质母细胞瘤是一种质母细胞瘤.恶性瘤是一种恶性瘤.基于纳米的siRNA输送系统

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