基础动脉封闭的治疗在轻度至中度重度中风患者的治疗
Simone Lieschke1,2, Simon Hellwig1,2, Christoph Riegler1,2
1Department of Neurology with Experimental Neurology Charité- Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin and Humboldt-Universität Berlin Berlin Germany.
内血管血栓切除术 (EVT) 加上静脉血栓溶解 (IVT) 并没有改善轻度至中度基底动脉阻塞中风的结果. 与单独IVT相比,这种EVT加IVT方法与较高的死亡率有关.
科学领域:
- 神经学 神经学
- 干预心脏病学 干预心脏病学
- 脑卒中医学 脑卒中医学
背景情况:
- 血管内血栓切除术 (EVT) 是为严重的基底动脉阻塞 (BAO) 中风而建立的.
- 它在轻度至中度BAO中风中的有效性仍然不确定.
- 这项研究在这个患者群体中研究了单独的EVT与IVT.
研究的目的:
- 为了比较EVT (有或没有IVT) 与单独IVT的有效性.
- 评估轻度至中度BAO患者的临床结果,死亡率和并发症.
- 为了为BAO中风管理的治疗指南提供信息.
主要方法:
- 利用了来自国际EVA-TRISP和TRISP合作的数据.
- 包括确诊BAO的患者,NIHSS得分<10,并在6小时内接受治疗.
- 分析结果包括功能状态 (mRS),死亡率和症状性内出血,使用回归和权重方法.
主要成果:
- 与176名EVT患者和98名IVT单独患者进行了比较.
- 在有利的结果中没有显著差异 (63.6%与64.3%).
- EVT与功能分布较差 (aOR 1.83),死亡率较高 (15.9%与6.1%相比;aOR 3.38),以及类似的出血率有关.
结论:
- 在轻度至中度的BAO中风中,EVT (带有或没有IVT) 并没有改善临床结果.
- 与单独IVT相比,EVT与死亡率的增加有关.
- 结果表明平衡,并强调需要在这个特定的患者群体中进行前性试验.
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