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妊娠期体重增加和早期儿童神经发育:前性队列研究
Weiying Liu1, Xuanshu Wang1, Feng Wu1
1Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China.
BJOG : an international journal of obstetrics and gynaecology
|January 29, 2026
概括
非常低的妊娠体重增加 (GWG) 和GWG轨迹的低终结与儿童的神经发育延迟的增加有关. 超重/肥胖母亲的GWG非常高也会增加这些延迟的风险.
科学领域:
- 孕产妇和儿童的健康
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 妊娠期体重增加 (GWG) 是影响母亲和婴儿结果的关键因素.
- 了解GWG模式对幼儿神经发育的影响对于公共卫生干预至关重要.
研究的目的:
- 调查妊娠期体重增加 (GWG) z-score及其轨迹与0-24个月龄儿童神经发育迟缓之间的关联.
主要方法:
- 这是一项前性研究,涉及中国深19702对单身母亲和单身子女.
- 基于组的轨迹建模被用来定义GWGz-score轨迹.
- 多变量后勤回归评估了GWG z分数,轨迹和神经发育延迟之间的关联,使用年龄和阶段问卷.
主要成果:
- 非常低的GWG (z-score <-1.5) 与沟通,总体运动技能,解决问题和个人社交技能延迟的风险增加有关.
- 在超重/肥胖的母亲中,非常高的GWG (z分数>1.5) 与解决问题的风险和个人-社会技能延迟的风险相关.
- 结束在低水平的GWG轨迹与神经发育延迟的更高风险有关.
结论:
- 非常低的GWG和结束于低水平的轨迹与神经发育迟缓的风险略有增加有关.
- 超重或肥胖的母亲过度使用GWG也会给儿童带来神经发育迟缓的风险.
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