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在ARVC中预测心律失常风险的左心室晚期加多增强.

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在心磁共振上,左心室晚期加多增强 (LV LGE) 与心律失常性右心室心肌病 (ARVC) 中心室心律失常 (VA) 风险有关. 然而,LV LGE并没有改善风险预测,超出现有的ARVC风险计算器.

关键词:
心律不整,心脏病,心脏病.死亡,突然,心脏病的死亡.心脏的心室是心脏的室内.预后 预后 预后风险评估 风险评估 风险评估

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科学领域:

  • 心脏病学 心脏病学
  • 医疗成像医学成像
  • 遗传学 是一个遗传学.

背景情况:

  • 节律失调的右心室心肌病变 (ARVC) 构成持续心室心律失常 (VA) 的风险.
  • 目前的ARVC风险计算器不包括左心室 (LV) 的结构或功能.
  • 在心磁共振 (CMR) 上的晚期加多增强 (LGE) 显示了预测心律失常事件的潜力.

研究的目的:

  • 确定CMR上的LV LGE是否可以增强ARVC患者VA风险分层.
  • 评估与已建立的ARVC风险计算器相比,LV LGE的增量预测值.

主要方法:

  • 一组385名没有先前VA的ARVC患者接受了基线CMR.
  • 使用生存分析和Cox比例危险模型来评估LV LGE对VA预测的影响.
  • 分析了高风险的LV LGE模式 (上心,外壁,结合隔膜/自由壁).

主要成果:

  • 132名患者 (34.3%) 患有LV LGE,其中98名 (25.5%) 呈现高风险模式.
  • 在随访期间 (3.1年),67名患者 (17.4%) 经历了VA.
  • 虽然LV LGE在无变量分析中与VA风险相关,但在调整了ARVC风险计算器得分后,它并没有独立预测VA.

结论:

  • 在ARVC患者中,LV LGE与VA风险有关.
  • 当与当前的ARVC风险计算器一起使用时,LV LGE不提供用于预测事故VA的额外预测信息.