在ARVC中预测心律失常风险的左心室晚期加多增强
Corrado De Marco1, Babken Asatryan2, Anneline S J M Te Riele3,4
1Cardiovascular Genetics Center and Electrophysiology Service, Montreal Heart Institute, Université de Montréal, QC, Canada (C.D.M., R.T., L.-P.D., J.C.-T.).
Circulation. Arrhythmia and electrophysiology
|January 29, 2026
概括
在心磁共振上,左心室晚期加多增强 (LV LGE) 与心律失常性右心室心肌病 (ARVC) 中心室心律失常 (VA) 风险有关. 然而,LV LGE并没有改善风险预测,超出现有的ARVC风险计算器.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 遗传学 是一个遗传学.
背景情况:
- 节律失调的右心室心肌病变 (ARVC) 构成持续心室心律失常 (VA) 的风险.
- 目前的ARVC风险计算器不包括左心室 (LV) 的结构或功能.
- 在心磁共振 (CMR) 上的晚期加多增强 (LGE) 显示了预测心律失常事件的潜力.
研究的目的:
- 确定CMR上的LV LGE是否可以增强ARVC患者VA风险分层.
- 评估与已建立的ARVC风险计算器相比,LV LGE的增量预测值.
主要方法:
- 一组385名没有先前VA的ARVC患者接受了基线CMR.
- 使用生存分析和Cox比例危险模型来评估LV LGE对VA预测的影响.
- 分析了高风险的LV LGE模式 (上心,外壁,结合隔膜/自由壁).
主要成果:
- 132名患者 (34.3%) 患有LV LGE,其中98名 (25.5%) 呈现高风险模式.
- 在随访期间 (3.1年),67名患者 (17.4%) 经历了VA.
- 虽然LV LGE在无变量分析中与VA风险相关,但在调整了ARVC风险计算器得分后,它并没有独立预测VA.
结论:
- 在ARVC患者中,LV LGE与VA风险有关.
- 当与当前的ARVC风险计算器一起使用时,LV LGE不提供用于预测事故VA的额外预测信息.
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