亚洲慢性淋巴细胞白血病患者的第二次原发性恶性瘤:台湾癌症注册研究
Yi-Wei Lee1, Chun-Ju Chiang2,3, Ying-Chu Lin4
1Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
British journal of haematology
|January 29, 2026
概括
患有慢性淋巴细胞白血病 (CLL) 的亚洲患者患第二次原发性恶性瘤 (SPMs) 的风险较高,特别是皮肤和膀癌. 在CLL的五年内早期诊断显著增加了SPM风险.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 第二次原发性恶性瘤 (SPMs) 是慢性淋巴细胞白血病 (CLL) 幸存者的一个担忧.
- 有限的数据存在于亚洲人群中SPM风险与CLL.
研究的目的:
- 评估在台湾大批患有CLL的患者中SPM的风险和模式.
- 为了确定特定的癌症类型和时间框架,与此种人群中增加的SPM风险相关.
主要方法:
- 全国范围的回顾性队列研究利用台湾癌症注册 (1991-2020).
- 包括2702名被诊断患有CLL的患者.
- 计算标准化发病率 (SIR),绝对超额风险和累积发病率与一般人口相比,按人口统计和治疗分层.
主要成果:
- 总体上,SPM风险增加 (SIR 1.14) 的五年累计发病率为6.53%.
- 显著增加了上皮皮肤癌 (SIR 2.55) 和尿膀癌 (SIR 1.99) 的风险.
- 在CLL诊断后5年内观察到更高的SPM风险 (SIR 2.72),随后下降 (SIR 0.67). 年轻女性的乳腺癌风险较低 (SIR 0.29).
结论:
- 与西方人口相比,台湾的CLL患者表现出明显的SPM风险概况.
- 膀癌的过度风险需要特别注意和监测.
- 针对性监测策略对于亚洲CLL患者来说至关重要,以有效地管理SPM风险.
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