缺少IGF-1作为一个综合生物标志物病原性驱动器和预测器在低水平的卵巢反应
Zhu Hu1, Yuanyuan Yu2, Guanyou Huang1
1Reproductive Medicine Center, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 29, 2026
概括
降低胰岛素样生长因子1 (IGF-1) 与在生育治疗中卵巢反应不良 (POR) 有关. 测量FF IGF-1提供了一种新的,准确的方法来预测POR并改善试管婴儿的结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
- 生物标志物发现发现
背景情况:
- 卵巢反应不良 (POR) 是辅助生殖技术 (ART) 的一个重大挑战.
- 目前的POR诊断方法和生物标志物缺乏可靠性.
- 识别可靠的生物标志物对于提高试管婴儿成功率至关重要.
研究的目的:
- 研究胰岛素样生长因子1 (IGF-1) 在卵巢反应不良 (POR) 中的作用.
- 确定IGF-1作为预测POR和IVF结果的潜在生物标志物.
- 开发基于IGF-1水平的POR新型临床预测工具.
主要方法:
- 在POR和正常卵巢反应 (NOR) 患者中测量了血清,卵泡液 (FF) 和粒状细胞 (GC) 的IGF-1水平.
- 在体内小鼠模型 (Igfals淘汰和Igf-1r淘汰) 用来确定因果关系.
- 使用FF IGF-1度开发了POR风险和妊娠结果的临床预测模型.
主要成果:
- 与NOR患者相比,POR患者在血清,FF和GC中显示出明显较低的IGF-1水平.
- FF IGF-1与关键的试管婴儿结果呈正相关性:MII卵细胞,2个原核的胚胎和高质量的胚胎.
- 基于FF IGF-1的新型预测工具显示出高准确度 (POR风险AUC=0.914,妊娠结果AUC=0.893),表现优于传统标记.
结论:
- 降低IGF-1信号与POR的病理生理学有关.
- 毛囊液IGF-1是POR和IVF成功的强有力的预测剂.
- 基于FF IGF-1的工具为早期识别和管理POR患者提供了重要的临床实用性.
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