使用Terminalia phanerophlebia生物合成的银纳米颗粒的表征,抗微生物和抗增殖活动. & Diels 公司
Folasade O Banji-Onisile1, Nneka A Akwu2, Tosin A Olasehinde1,3
1Department of Microbiology, School of Life Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
Cell biochemistry and function
|January 29, 2026
概括
从Terminalia phanerophlebia合成的银纳米粒子 (AgNPs) 具有强大的抗微生物和抗癌特性. 这些植物衍生的AgNP显示出作为可持续的治疗剂对各种感染和癌症细胞系的承诺.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物技术是生物技术.
背景情况:
- 纳米粒子 (NP) 越来越多地被探索用于治疗微生物感染和癌症的治疗应用.
- 银纳米粒子 (AgNPs) 具有独特的物理化学特性,使其适合用于医疗用途.
研究的目的:
- 从Terminalia phanerophlebia根和叶提取物中合成和描述AgNP.
- 评估合成的AgNP的抗菌和细胞毒性活动.
主要方法:
- 使用T. phanerophlebia根和叶的水性提取物合成AgNP.
- 使用FTIR,SEM/EDX,TEM和XRD进行表征.
- 对细菌和真菌分离物的抗微生物测定.
- 对HepG2,MCF-7和HEK293细胞系进行细胞毒性测定.
主要成果:
- 合成了具有平均尺寸为46nm (根) 和41nm (叶) 的球形和立方AgNP.
- AgNPs对测试的细菌和真菌表现出显著的抗菌活性,叶子AgNPs对MRSA表现出最高的抑制作用.
- 根AgNP和叶AgNP对HepG2和MCF-7癌细胞呈现强烈的细胞毒性作用,对正常的HEK293细胞毒性较低.
- 在癌症细胞系中,由合成的AgNP诱导了亡.
结论:
- 来自T. phanerophlebia的AgNP具有显著的抗微生物和抗癌潜力.
- 这些AgNP可以被认为是开发新型治疗剂的可持续替代品.
- 这些发现强调了这些纳米粒子的抗菌,抗真菌,抗增殖和诱导亡的能力.
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