在鼻癌中人类乳头瘤病毒的行为风险因素和血清流行率:一个多机构病例控制研究
Ved Tanavde1, Anuj Tharakan1, Gypsyamber D'Souza2
1Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
人类乳头瘤病毒相关的鼻癌 (HPV-SNC) 显示出独特的血清学标志物,但缺乏明确的行为风险因素. 桃体切除术可以预防HPV-SNC,这表明淋巴细胞组织在其发展中发挥了作用.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 鼻癌是一种罕见的,攻击性的癌症.
- 一个子集与高风险的人类乳头瘤病毒 (HPV) 有关.
- 与HPV相关的鼻癌 (HPV-SNC) 和HPV独立性疾病的风险因素尚不清楚.
研究的目的:
- 调查HPV-SNC和HPV独立性鼻癌的行为和临床风险因素.
- 评估这些疾病患者的HPV抗体血清阳性.
主要方法:
- 一项多机构病例控制研究,涉及52名鼻癌患者和148名对照人群.
- 电子调查收集了人口统计,行为和病史数据.
- 血清检测发现了针对HPVcoproteins的抗体.
主要成果:
- 桃体切除术的病史与HPV-SNC的几率降低有关 (或0.28).
- 没有其他行为或临床因素与HPV-SNC或HPV独立的SNC有关.
- 抗HPV16E6的血清流行率在HPV-SNC病例中明显高于对照和HPV独立的SNC.
结论:
- HPV-SNC具有明显的血清学特征,但没有明确的行为风险因素.
- 桃体切除术的保护性关联表明淋巴组织参与HPV-SNC瘤发生.
- 需要进一步的研究来确定HPV独立性SNC的危险因素.
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