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在Stargardt病中测距微观测量:应用和可靠性
Sybren H Kootstra1, Jeroen A A H Pas1,2, Patty P A Dhooge1
1Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, GA, The Netherlands.
半平面微观测量 (mMP) 在Stargardt病类型1 (STGD1) 试验中显示了可变的测试-重复测试结果. 平均灵敏度 (MS) 比点式灵敏度 (PWS) 更可靠,测试时间较短可以提高一致性.
科学领域:
- 眼科医生 眼科 眼科
- 临床试验 临床试验
- 视觉电生理学 视觉电生理学
背景情况:
- 间距微观测量 (mMP) 是对STGD1类型的Stargardt病的临床试验的关键功能结果测量.
- 评估mMP的测试-重新测试可变性对于确保试验结果的可靠性至关重要.
研究的目的:
- 评估在患有STGD1.1的患者中测距微观测量 (mMP) 的测试-再测试可变性.
- 确定影响mMP变异性的因素,包括固定稳定性和考试持续时间.
主要方法:
- 在STARTT试验中的68名STGD1患者中的115只眼睛在两次访问中使用MAIA微圈仪进行了mMP测试.
- 使用布兰德-阿尔特曼分析和可重复性系数 (CoR) 评估了测试-重试变异性.
- 分析了平均灵敏度 (MS) 和定点灵敏度 (PWS),以及固定稳定性和检查持续时间.
主要成果:
- 平均灵敏度 (MS) 显示出较低的变化 (CoR:3.53dB) 与点性灵敏度 (PWS) (CoR:12.69dB) 相比.
- 增加的变性与更长的测试持续时间和更高的固定损失有关.
- 中部地区和特定灵敏度范围的变异性较低;没有观察到学习效应.
结论:
- 由于STGD1试验的高可变性,应谨慎使用点向灵敏度 (PWS).
- 平均灵敏度 (MS) 提供了更好的可靠性,但可能会掩盖局部功能缺陷.
- 建议优化测试时间 (≤450秒) 和操作员培训,以提高mMP的可靠性.
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