通过综合性转录和机器学习分析,揭示EMT相关的分子机制
Şehriban Büyükkılıç1,2, Hani Alotaibi1,2, Alexandros G Georgakilas3
1Izmir Biomedicine and Genome Center, 35340 Izmir, Türkiye.
Frontiers in bioscience (Landmark edition)
|January 29, 2026
概括
表皮-介质细胞过渡 (EMT) 驱动正常发育和癌症. 这项研究揭示了癌症EMT中独特的基因表达模式,包括神经程序,并确定了瘤入侵的潜在生物标志物.
科学领域:
- 分子生物学分子生物学
- 发育生物学 发展生物学
- 癌症生物学 癌症生物学
背景情况:
- 表皮-介质细胞过渡 (EMT) 对癌症的发展和进展至关重要.
- EMT驱动瘤入侵和转移,但生理和癌症EMT之间的差异尚不清楚.
研究的目的:
- 确定生理和癌症相关EMT之间的转录差异.
- 识别和优先考虑涉及EMT的基因和途径.
- 为了发现潜在的EMT生物标志物.
主要方法:
- 89个小鼠RNA测序数据集的综合分析.
- 转录形状分析,功能丰富分析和机器学习.
- 正常和恶性背景的比较.
主要成果:
- 在正常和癌症EMT中共享的通路包括细胞粘附和形态发生.
- 癌症EMT独特地显示了神经发育程序 (神经发生,质发生) 的丰富.
- 机器学习确定了在癌症中异质性更高的候选EMT生物标志物.
结论:
- 截然不同的转录特征区分恶性与生理EMT.
- 癌症中神经程序丰富EMT表明细胞可塑性的机制.
- 确定了EMT异质性的候选生物标志物.
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