过敏性鼻炎的严重程度对炎症特征,鼻功能,焦虑和抑郁的影响
Wei Han1, Xiuming Pang2, Xinpeng Yang2
1Department of Otolaryngology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, 150000 Harbin, Heilongjiang, China.
British journal of hospital medicine (London, England : 2005)
|January 29, 2026
概括
过敏性鼻炎 (AR) 的严重程度会恶化炎症,鼻功能障碍和心理健康. 中度至重度的AR显示焦虑,抑郁,鼻功能和炎症之间的相关性比轻度的AR更强.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 精神病学是一个精神病学.
背景情况:
- 过敏性鼻炎 (AR) 是一种常见的上呼吸道疾病,影响患者的福祉.
- 对AR严重程度对炎症标志物,鼻功能和心理健康的影响需要进一步阐明.
研究的目的:
- 调查过敏性鼻炎严重程度对炎症因素,鼻子功能以及焦虑和抑郁的患病率的影响.
主要方法:
- 188名AR患者的回顾性分析,分为轻度 (n=90) 和中度/重度 (n=98) 组,与79名健康对照组相比.
- 评估鼻气道阻力 (NAR),鼻膜清除时间 (NMCT),医院焦虑和抑郁 (HAD) 尺度以及血清/鼻水炎症标志物 (CRP,PCT,IL-1β,TNF-α).
主要成果:
- 与对照组相比,AR患者的炎症标志物水平显著提高,鼻功能受损 (NAR,NMCT) 和HAD得分增加 (p <0.05).
- 中度/重度AR组显示显著增加的炎症生物标志物,更差的鼻功能,和比轻度AR组更高的HAD得分 (p <0.05).
- 焦虑和抑郁与鼻功能和炎症相关,在中度/重度AR组中观察到更强烈的关联.
结论:
- 在AR中,疾病的严重程度与炎症增加和心理困扰 (焦虑/抑郁) 与鼻子功能下降相关.
- 焦虑,抑郁,鼻功能和炎症之间的关系在中度/重度过敏性鼻炎患者中更加明显.
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