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Updated: Jan 31, 2026

Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
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视网膜和毛细胞厚度和年龄在的发展和衰老

Lingli Zhou1,2, Yingxue Cao1,2, Folahan Adesola Ibukun1,3

  • 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Investigative ophthalmology & visual science
|January 29, 2026
PubMed
概括

Cynomolgus的视网膜层在年轻时变厚,在年老时变薄,反映了人类的衰老. 两种物种随着年龄的增长而增加的毛囊厚度表明与衰老相关的重塑,验证了作为视网膜衰老研究的模型.

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Cellular Clock Theory
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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