从海中提取的新型多糖体的结构特征和抗炎活性分析
Xiaoge Li1, Kaixuan Wang1, Qibao Jiang1
1State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Journal of the science of food and agriculture
|January 29, 2026
概括
两种新的海多糖,SBP50-0和SBP70-0,通过抑制巨细胞中的氧化和促炎媒介体,表现出显著的抗炎作用,展示了它们的治疗潜力.
科学领域:
- 植物化学 植物化学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 海 (Hippophae rhamnoides) 是一种具有已知的生物活性多糖的药用植物.
- 海多糖的确切结构和抗炎机制尚不清楚.
- 本研究的重点是从海中分离出来的新型多糖体SBP50-0和SBP70-0.
研究的目的:
- 从海中分离和净化新型的多糖.
- 阐明SBP50-0和SBP70-0.0的详细结构.
- 评估这些多糖的体外抗炎活性.
主要方法:
- 聚糖的分离和净化.
- 使用甲基化和NMR光谱学进行结构性表征.
- 在体外抗炎试验中,使用脂多糖刺激的RAW264.7巨细胞进行了抗炎试验.
主要成果:
- 确定了两个同质的中性多糖体,即SBP50-0 (1.04 × 104 Da) 和SBP70-0 (6.45 × 103 Da).
- 这两种多糖都具有独特的,高度分支的结构,由曼诺斯,银河糖,葡萄糖,拉姆诺斯和阿拉比诺斯组成.
- SBP50-0和SBP70-0显著抑制了氧化的产生,并抑制了关键的促炎介质 (IL-6,TNF-α,iNOS).
结论:
- SBP50-0和SBP70-0显示出强大的抗炎性质.
- 它们的生物活性与独特的分支结构有关,包括阿拉伯银河系的侧链和富含曼诺斯的图案.
- 这些海多糖体显示出开发天然抗炎功能食品和制药剂的前景.
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