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爬山的亚慢性双-A毒性,Anabas testudineus:对代谢干扰,氧化应激和组织病理变化的洞察
Dhivakar Vadivel1, Tincy Varghese1, Neeraj Kumar2
1ICAR-Central Institute of Fisheries Education, Mumbai, India.
Environmental toxicology
|January 29, 2026
概括
来自双甲 (BPA) 等化学品的微塑料污染威胁着渔业. 即使是低剂量的BPA也会显著影响爬的免疫生理学和压力生物标志物,影响水生生态系统.
科学领域:
- 环境毒理学环境毒理学
- 水生物质毒理学研究
- 鱼类生理学 鱼类生理学
背景情况:
- 水产养殖和渔业面临气候变化和污染的威胁.
- 微塑料无处不在,影响食物链,并释放诸如双-A (BPA) 等增塑剂.
- 由于BPA的广泛存在,它在水生环境中引起了重大关注.
研究的目的:
- 调查登杆 (Anabas testudineus) 上亚致命双甲 (BPA) 剂量的免疫生理学和本病理学影响.
- 为了确定BPA的中位数致命度 (96h-LC50) 的Anabas testudineus.
- 评估BPA对氧化应激,酶活性和登杆中的基因表达的影响.
主要方法:
- 确定了 Anabas testudineus 的 BPA 的 96h-LC50.
- 鱼类暴露于BPA的次致命剂量 (0.419,0.838,1.677 ppm). 鱼类暴露在BPA的次致命剂量 (0.419,0.838,1.677 ppm) 的次致命剂量.
- 分析了免疫生理学参数,氧化应激标志物,酶活动 (肝脏和大脑),压力生物标志物和基因表达.
主要成果:
- BPA的96h-LC50被确定为16.77 ppm.
- 暴露于BPA会增加红细胞和白细胞数量,氧化应激 (SOD,催化酶) 和肝酶活性 (AST,ALT).
- 脑组织中的乙胆酶被抑制,血清葡萄糖和HSP水平增加,特定基因 (HSP,iNOS,CAS 3a,CYP450) 被上调,而其他 (TNFα,Ig) 被下调.
结论:
- 亚致命性BPA暴露显著影响了Anabas testudineus中的免疫生理和压力生物标志物反应.
- 即使是低剂量的BPA (0.419 ppm) 也会严重影响鱼类的压力生物标志物.
- 研究结果强调了BPA污染对鱼类健康和水生生态系统的有害影响.
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