85岁及以上成年人血压,功能状态和认知功能的时间动态:莱登85岁以上研究中的动态时间扭曲方法
Jan J Duin1,2, Stella Trompet1,2, Erik Giltay3,4
1Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Age and ageing
|January 29, 2026
概括
老年人血压 (BP) 的变化可能预测未来的功能和认知能力下降. 监测老年人血压趋势对于预测健康变化至关重要.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
背景情况:
- 高血压 (BP),功能衰退和认知衰退在老年人中经常同时发生.
- 血压波动与随后的功能或认知状态变化之间的精确时间关系尚不清楚.
研究的目的:
- 在85岁及以上的成年人中调查血压变化和随后的功能或认知衰退之间的时间动态.
- 利用动态时间扭曲 (DTW) 来分析这些复杂的时间关系.
主要方法:
- 采用了来自莱登85+研究的数据,包括5年的血压,功能状态 (ADL/IADL) 和认知功能 (MMSE) 测量.
- 包括429名85岁以上的参与者,每年至少进行三次测量.
- 应用动态时间扭曲 (DTW) 来评估BP变化与功能/认知结果之间的时间关联.
主要成果:
- 随着时间的推移,血压的增加与随后的日常生活工具活动 (IADL) 的下降有关.
- 相反,血压下降与以后的IADL改善有关.
- 截流血压的下降先后导致迷你精神状态检查 (MMSE) 得分的下降,而截流血压的增加与MMSE的改善有关.
结论:
- 生命晚期的血压变化与随后的功能状态 (IADL) 的反向变化有关.
- 扩张性血压变化似乎在认知功能 (MMSE) 的平行变化之前发生.
- 这些发现强调了监测老年人血压趋势的重要性,因为这些趋势是未来功能和认知衰退的潜在指标.
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