辅助益生菌疗法通过肠道微生物组-代谢组重塑维持胃食道逆流病的症状缓解
Yingmeng Li1,2,3,4,5,6, Qiong Li5,7, Keyu Quan1,2,3,4
1Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
mSystems
|January 29, 2026
概括
与安慰剂相比,RABEPRAZOLE的辅助益生菌治疗显著降低了GERD症状,改善了肠道微生物群. 这种方法支持持续缓解症状和使用质子抑制剂后微生物代谢平衡.
科学领域:
- 胃肠道学和微生物组研究
- 临床试验和多组学分析
背景情况:
- 长期使用质子抑制剂 (PPI) 治疗GERD可能导致肠道失调和症状复发.
- 益生菌显示出调节肠道生态系统的潜力,并在GERD管理中提供辅助益处.
研究的目的:
- 为了评估多菌株益生菌 (Lihuo) 结合拉贝普拉在GERD患者的疗效.
- 评估辅助益生菌治疗对GERD肠道微生物群和代谢物的影响.
主要方法:
- 这是一项为期12周的随机,双盲,安慰剂对照试验,涉及120名GERD患者.
- 干预涉及RABEPRAZOLE与Lihuo益生菌或安慰剂一起服用8周,随后仅服用益生菌/安慰剂4周.
- 结果包括反流性疾病问卷 (RDQ) 评分,症状评级,内镜治疗,以及中枪元基因组学,菌群和代谢学概况.
主要成果:
- 与安慰剂相比,益生菌组的RDQ得分显著减少36.51% (P=0.017).
- 转基因组学揭示了诸如Bifidobacterium animalis和Lactiplantibacillus plantarum之类的有益细菌的丰富性.
- 代谢学表明,加玛-氨基黄油酸,糖酸,素和短链脂肪酸的水平增加,与微生物代谢物相关.
结论:
- 辅助益生菌疗法在GERD患者中维持PPI后症状缓解.
- 益生菌干预调节肠道微生物群组成和生物活性代谢物概况.
- 这种方法支持微生物代谢平衡,并增强了GERD的症状控制.
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