塞夫特里亚克松与Piperacillin-Tazobactam单疗法用于开放骨折预防:一个回顾性队列研究
A Hampton Sisson1, Robin M Litten2, Ryan N McIlwain2
1Heersink School of Medicine, University of Alabama at Birmingham; Birmingham, AL.
Journal of orthopaedic trauma
|January 29, 2026
概括
塞夫特里亚克松 (CTX) 和皮佩拉西林-塔佐巴克坦 (PIP-TAZ) 在开放骨折患者中显示出类似的骨折相关感染 (FRI) 和急性损伤 (AKI) 率. 糖尿病是FRI的一个重要风险因素.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 开放性骨折具有较高的并发症风险,如骨折相关感染 (FRI) 和急性损伤 (AKI).
- 抗生素预防对于管理开口骨折以预防感染至关重要.
- 塞夫特里亚克松 (CTX) 和皮佩拉西林-塔扎巴克坦 (PIP-TAZ) 是常用的抗生素,但它们在这种情况下的比较疗效和安全性需要进一步研究.
研究的目的:
- 为了比较FRI和AKI的发病率,成年患者有开放性骨折,接受了单独治疗的塞夫triaxone (CTX) 或单独治疗的piperacillin-tazobactam (PIP-TAZ).
- 在这个患者群体中确定与FRI相关的潜在风险因素.
主要方法:
- 从2020年到2023年在一级创伤中心进行的回顾性队列研究.
- 包括患有骨,骨,腰骨,半径/骨和脚骨折的成年患者,接受手术灌和除.
- 排除了不到6个月的随访,转移医院,首次截肢,在48小时内使用香素或复杂的重建手术的患者.
主要成果:
- 136名患者符合纳入标准 (67名CTX,69名PIP-TAZ).
- 在两组之间没有观察到FRI率 (25.4%CTX与29.0%PIP-TAZ) 或AKI率 (11.9%CTX与15.9%PIP-TAZ) 的统计学上显著差异.
- 多变量分析确定糖尿病是FRI的一个显著的独立风险因素 (OR 6.62,p = 0.003).
结论:
- 塞夫特里亚克松和皮佩拉西林-塔扎巴克坦在患有开口骨折的患者中,在FRI和AKI方面显示出可比的安全性和有效性概况.
- 糖尿病是一种显著的风险因素,增加了患骨折相关感染的可能性.
- 可能需要进一步的前性研究来证实这些发现.
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