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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
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A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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表达驱动的遗传依赖揭示了精确瘤学的目标.

Abdulkadir Elmas1, Hillary M Layden2, Jacob D Ellis2

  • 1Department of Genetics and Genomic Sciences, Department of Artificial Intelligence and Human Health, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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概括

这项研究引入了BEACON,一种通过观察基因表达,而不仅仅是突变来寻找新的癌症药物标的方法. 它确定了表达驱动的依赖性,以扩大更多患者的精确瘤学选择.

关键词:
标签: 标志 标志 标志 标志 标志 标志贝叶斯统计学 贝叶斯统计学精确瘤学是一门精确的专业.癌症细胞系癌症细胞系癌症的脆弱性 癌症的脆弱性毒品目标是毒品的目标.由表达驱动的依赖性.多种主题的多种主题.蛋白质组学 蛋白质组学翻译学 翻译学 翻译学 翻译学

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科学领域:

  • 基因组学就是基因组学.
  • 癌症生物学 癌症生物学
  • 计算生物学 计算生物学

背景情况:

  • 癌细胞表现出异质性,具有多样化的分子变化.
  • 基于DNA突变的向疗法受到许多瘤中缺乏可药物向的点的限制.

研究的目的:

  • 通过表达驱动的依赖来识别新的精确瘤学目标.
  • 基于高基因表达水平,探索癌细胞的脆弱性.

主要方法:

  • 开发了BEACON,这是一个贝叶斯的方法,集成了转录基因,蛋白质基因和遗传依赖数据.
  • 分析了17个组织系的癌症细胞系的数据.

主要成果:

  • BEACON确定了已知的可药物基因 (例如,BCL2,MYC) 和新的点.
  • 丰富用于已批准的药物标 (3.8倍) 和可药物瘤标 (7-10倍).
  • 实验验证证了GRHL2,TP63和PAX5作为有效的标.

结论:

  • 该方法通过表达驱动依赖系统地识别精确瘤学目标.
  • 集成多主题和依赖屏幕,提供全面的目标目录.
  • 扩大了癌症治疗的基因突变策略之外的治疗选择.