乳清蛋白补充剂在老年人中积极调节肺功能和肺和全身免疫反应:一项随机对照临床试验
Meiry Souza Moura-Maia1, Rosa Helena Ramos Paula-Vieira1, Nycole Vieira Ramos-Gomes1
1Laboratory of Pulmonary and Exercise Immunology, Evangelical University of Goias (UniEvangélica), Anápolis, Brazil.
Journal of the American Nutrition Association
|January 29, 2026
概括
隔离乳清蛋白补充剂 (IWPS) 增强了老年人的免疫反应和肺功能. 这项为期3个月的干预措施改善了肺和全身免疫力,以及身体能力.
科学领域:
- 老年学是指老年学的学科.
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 老龄化与蛋白质摄入量下降,免疫力减弱和感染风险增加有关.
- 虽然乳清蛋白有益于全身免疫力,但其对老年人肺免疫力的影响尚不清楚.
研究的目的:
- 研究孤立乳清蛋白补充剂 (IWPS) 对老年人肺免疫反应的影响.
- 评估IWPS对肺功能,全身免疫力,肌肉力量和功能能力的影响.
主要方法:
- 一个为期3个月的临床试验,涉及两个组:对照组 (n=38) 和IWPS (n=27).
- 参与者每天接受25g的IWPS.
- 主要结局是肺免疫反应;次要结局包括肺功能,全身免疫力,肌肉强度和身体组成.
主要成果:
- IWPS显著改善了肺功能 (FEV1,FEV1/FVC,FEF25-75%,PEF) 并减少了气道炎症标志物 (FeNO,IL-6,TNF-α).
- 补充剂增加了呼吸凝析中的抗炎 (IL-10) 和抗衰老 (Klotho) 标志物.
- 系统性免疫反应得到改善,白细胞和促炎性细胞因子 (IL-6,TNF-α) 减少,IL-10和Klotho水平增加.
- 功能能力,呼吸道肌肉强度和外周肌肉强度得到增强.
结论:
- 隔离乳清蛋白补充剂有效地改善了老年人的肺和全身免疫反应.
- IWPS对肺功能产生积极影响,并提高老年人群的整体功能能力.
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