在患有刺激性肠综合征的患者中自我报告的非腹性谷蛋白敏感性:横截面分析
Viviana Fara Brindicci1, Fernanda Cristofori1, Simone Franceschini2
1Interdisciplinary Department of Medicine, Pediatric Section, University of Bari "Aldo Moro", Children's Hospital "Giovanni XXIII", Bari, Italy.
Journal of clinical gastroenterology
|January 29, 2026
概括
近30%的成年人患有刺激性肠综合征 (IBS) 也有非乳性谷蛋白敏感性 (NCGS). 在IBS患者中识别NCGS可能会改善治疗策略和症状管理.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 饮食科学 饮食科学
背景情况:
- 非乳性谷蛋白敏感性 (NCGS) 和易怒肠综合征 (IBS) 呈现重叠的症状,使得差异诊断具有挑战性.
- 肠胃综合征是一种功能性胃肠道疾病,而NCGS则涉及没有乳病或小麦过敏的个体的质诱导症状.
研究的目的:
- 根据罗马四号标准,确定根据罗马四号标准诊断出易怒肠综合征 (IBS) 的年轻意大利成年人自我报告的非性谷蛋白敏感性 (NCGS) 的患病率.
- 探索NCGS和IBS之间的关联,包括症状概况和饮食习惯.
主要方法:
- 在2022年1月至3月期间,在5108名意大利年轻成年人中进行了一项横截面调查.
- 经过验证的调查问卷评估了人口统计数据,罗马IV IBS诊断,与质相关的症状和无质饮食 (GFD) 的坚持.
- 统计分析,包括t测试和费舍尔精确测试,用于比较组.
主要成果:
- 在5108名参与者中,819人 (16%) 符合IBS的罗马IV标准. 其中,238个 (29.1%) 也符合NCGS的标准.
- 与非IBS组 (8.6%) 相比,在IBS组 (29.1%) 中NCGS的患病率明显高.
- 与没有NCGS的IBS患者 (40.5%) 相比,有NCGS的IBS患者报告了更多的肠外和神经精神症状和更高的GFD坚持 (60.9%).
结论:
- 大约30%的IBS患者也符合NCGS的标准,这表明有很大的重叠.
- 在IBS患者中,NCGS与明显的肠外症状和采用无质饮食的可能性更高有关.
- 在IBS患者中确定NCGS可能会导致改善症状管理和量身定制的治疗策略.
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